Bio X4 Reviews 2023: Does It Really Work?

Dr. Nicolette Natale, DO
Dr. Kimberly Langdon, MD

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Bio X4 reviews have been consistently positive, but is there any real science behind the claims? Click here to find out.
bio x4 reviews
Bio X4 is designed to help with weight loss and gut health. Photo: Team Design

People interested in weight management and health promotion are often inundated with a barrage of nutritional supplements that they feel they need to take to get everything right. Instead of purchasing multiple monthly products, Nucific simplifies this process with their 4-in-1 weight loss probiotic Bio X4 dietary supplement.

Bio X4 is a science-backed blend of probiotics and other craving curbing and fat-burning ingredients that support weight maintenance and digestion. Their unique blend of ingredients was designed with its users in mind to simplify their daily health maintenance routine to one simple supplement.

But is Bio X4 worth all the hype?

In this article, we will explore Bio X4 reviews, look inside the company behind the product Nucific, and dive into the evidence behind the ingredients they use. Hopefully, this will help you decide if Bio X4 is the right addition to your weight loss and digestive support plan.

  • Supports healthy digestion
  • Gluten-free and allergen-free
  • Third-party tested
  • High price
  • Mixed research to support claims
  • Non-traceable ingredients


Bio X4 Reviews


Nucific was created by board-certified physician Dr. Amy Lee to help patients achieve the best health of their lives. Nucific tests the quality of each batch of Bio X4 at an independent third-party facility to ensure the safety and purity of the product.

Although the supplement is gluten-free and allergen-free, allergies have been reported to some of the ingredients, including green tea.[1] Any new supplement with ingredients you have not been exposed to can cause allergic reactions, so always check with your doctor if you begin experiencing any new symptoms after starting this supplement.

Bio X4 Ingredients Analysis

Bio X4 Ingredients
Bio X4 Ingredients
Probiotic Blend

If you are wondering how to improve gut health, look no further than probiotic supplements. Probiotics are naturally occurring live microorganisms that are known to improve gut health, particularly in those with functional bowel disorders like irritable bowel syndrome. The probiotic supplement blend in Bio X4 is designed to promote a healthier gut. It contains 4 billion CFU per capsule and is a blend of lactobacillus and bifidobacterium probiotic strains. 

Lactobacillus Blend

Lactobacillus probiotic strains have immune-supportive effects and have been demonstrated[2] to improve certain gastrointestinal infections such as H. pylori, reduce the occurrence of vaginal candidiasis, and relieve constipation and diarrhea. The lactobacillus blend contains three strains of lactobacillus:

  • Acidophilus.
  • Rhamnosus.
  • Plantarum. 

Each strain has unique benefits that can help improve digestion and restore immune function through restoring good bacteria. 

Bifidobacterium Blend

Bifidobacteria are naturally occurring in the microbiome of the colon. As a probiotic agent, it has been demonstrated[3] to treat certain intestinal infections, improve constipation and diarrhea, and provide antimicrobial properties to prevent certain infections. The bifidobacterium blend contains two bifidobacteria strains, namely lactis and animallis. These strains help support healthy immune function, promote healthy bacteria, and restore digestive health. 

Digestive Enzyme Blend

The digestive enzymes are a combination of specialized proteins that help break down the food you eat to assist in nutrient absorption, improving energy, and reducing digestive symptoms. The blend contains 43 mg of a combination of the following three enzymes:  

  • Amylase – A naturally produced digestive enzyme[4] that breaks down starches into more easily digestible sugars. Low levels of this enzyme have been linked[5] to the development of metabolic syndromes like diabetes and obesity.
  • Bromelain – Protein-digesting enzyme derived from pineapples. It has anti-inflammatory,[6] antimicrobial, antitumor, and antidiarrheal effects.
  • Lipase – A naturally produced digestive enzyme that breaks down fats.[7] It is crucial for the absorption of fat-soluble vitamins such as vitamins A, D, E, and K.

The digestive enzymes may help support nutrient absorption, proper digestion, and immune function.

Weight Management Blend 

If you want to lose weight fast, then a weight management supplement may be something you are researching. The weight management blend contains 100 mg of green tea extract, which naturally contains 50% of EGCG. Green tea has many health benefits,[8] such as anti-inflammatory, antimicrobial, antioxidative, preventing cancer, and reducing cholesterol.

Research[9] has shown that supplementation with green tea extract may result in weight loss in obese subjects and overweight individuals.

Craving Control Blend

Bio X4’s craving control blend contains 166 mg of slimaluma, a patented Caralluma Fimbriata extract. For many people on a weight loss journey, cravings can get in the way.

Caralluma extract is an essential addition to Bio X4, as it has been shown to reduce appetite[10] in children with a rare genetic condition called Prader-Willi Syndrome. Some research[11] has also supported its use in reducing hunger levels and supporting weight loss in obese and overweight individuals. Other studies[12] have failed to show any improvements in appetite suppression in this population.

Support Research

Claimed Benefits Of Bio X4
Manage CravingsLitte Evidence
Promote Weight ManagementModerate Evidence
Boost MetabolismModerate Evidence
Support Smoother DigestionConcrete Evidence
Claimed Benefits

Bio X4 nutritional supplement makes four main claims that range in scientific support. 

  1. Manage cravings.
  2. Promote weight management.
  3. Boost metabolism.
  4. Support smoother digestion.

Manage Cravings

The scientific evidence to manage cravings is lacking. Bio X4 claims to manage cravings by using Caralluma Fimbriata extract in its supplement blend. This extract, although proven effective[13] in curbing food cravings in children with Prader-Willi Syndrome, has inconsistent[14] results in the use of appetite suppression in overweight and obese individuals. 

Promote Weight Management

Some evidence[15] supports EGCG’s weight loss benefits and potential properties to prevent metabolic syndromes. There has been some mixed evidence in human studies using EGCG to aid weight loss and management, but the majority have demonstrated beneficial[16] effects for most individuals. 

Boost Metabolism

Bio X4 claims to boost metabolism through the use of green tea extract. Although there is evidence to support[17] the benefits of green tea extract in lowering blood glucose levels in people with metabolic syndromes like diabetes, there is mixed research regarding its usefulness in boosting metabolism in healthy individuals. 

Support Smoother Digestion

Bio X4 does a great job at providing science-backed ingredients to support smoother digestion. The probiotic[18] blend contains strains that improve functional bowel issues such as constipation and diarrhea. 

The digestive enzyme[19] blend effectively breaks down the diet’s starches, proteins, and fats to promote proper nutrient absorption. This will all culminate in smoother digestion with fewer abdominal symptoms and a more balanced gut bacteria.

Bio X4


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Bio X4 Reputation

Bio x4 Nucific reviews have given this supplement a relatively strong reputation. Bio X4 is widely used and popular among dieters and health-conscious consumers alike.

They have GMP registration, meaning the product is manufactured using industry best practices. They are also registered with the Better Business Bureau (BBB) and have an A+ rating according to the BBB.

The Nucific Bio x4 reviews are not as high, with a rating of 3.45/5 on the BBB website out of 88 reviews. Most reviews report positive effects such as weight loss, digestive improvements such as reduction in bloating and gas, and improved energy. Some negative reviews included difficulties with customer service, issues returning the supplement, and unwanted side effects such as abdominal discomfort. 

Reviews of Bio X4 are even stronger on the Nucific website, with a 4.5/5 star rating out of almost 4,000 reviews. But, keep in mind this may be biased as Nucific can moderate what reviews they publish on their site


Bio X4 is quite expensive for a probiotic blend, with a $99 price tag per bottle of 90 capsules. The website does advertise many sales and deals, which makes the price come down closer to $49 a bottle if you can snag a coupon.

If the price tag is holding you back, Nucific does offer a 90-day money-back guarantee for first-time buyers, which may offset some anxiety with trying a new pricey product.

Alternatives To Bio X4

bio x4 reviews

Gundry MD 24 Strain Probiotic

  • Greater diversity of probiotic strain.
  • Higher CFU count.
  • Less expensive ($65).
  • Does not contain ingredients to support weight loss.
  • May lead to bloating at the start.
bio x4 reviews

Gundry MD Total Restore

  • Helps restore regular bowel movements.
  • Has antibacterial and antimicrobial properties.
  • Ingredients can cause potential drug interactions.
  • No probiotic strains.
bio x4 reviews

Gundry MD Bio Complete 3

  • Contains prebiotics, probiotics, and postbiotics to restore gut health.
  • Supports immune function.
  • Fewer probiotic strains.
  • No targeted metabolism boosting ingredients.

Health Benefits Of Bio X4

Bio X4 probiotic blend may improve overall health by improving the digestive process and immune function in individuals with a gut microbiome imbalance. This may also help with energy levels and relieve constipation or diarrhea.

Additionally, the combination of green tea and Caralluma Fimbriata may help with weight loss by curbing appetite and promoting fat burning.

How much weight do you need to lose to notice a difference? That often varies from person to person, but losing around 14–18 pounds will result in visible changes and differences in your body.
Green tea may be beneficial for improving metabolism,[20] especially in those with metabolic disorders.

Potential Side Effects

Probiotics are generally safe for most healthy individuals, although they may cause minimal[21] side effects. People with digestive disorders such as short bowel syndrome should consult with their physician beforehand.

Common side effects of probiotics include digestive problems like bloating and flatulence, and skin disturbances. If you experience these symptoms after starting Bio X4, immediately stop the supplement and check in with your healthcare provider.

The other ingredients in Bio X4 are also generally well tolerated. Caralluma Fimbriata is well-tolerated, with mild side effects, such as constipation, palpitations, and nausea. High doses[22] of ECGC have also been shown to be safe.

According to Nucific, some consumers may have an adverse response to some ingredients, although reviews for Bio x4 have been primarily positive. This is why it is crucial to read the product labeling and specifications before consuming to determine whether any ingredients may create an adverse reaction.

Additionally, pregnant or lactating individuals should speak with their healthcare provider before beginning this product. Before starting any new supplement or nutritional support, you should always check in with your healthcare provider to ensure it is safe, especially if you have a pre-existing medical condition.

How To Take Bio X4

For optimal results, take one capsule of Bio X4 with three meals three times per day. According to their website, you can take up to two capsules per meal, but do not take more than six capsules daily. If you miss a dose, continue as usual the following day.


Bio X4 is a four-in-one probiotic to manage cravings, promote weight loss, boost metabolism, and improve digestion. Unfortunately, in many of these categories, the scientific evidence falls short.

Two of the main ingredients, green tea extract and Caralluma Fimbriata, have limited evidence to back the company’s claims about their ability to boost metabolism and curb hunger. On the other hand, their digestive enzyme and probiotic blend are science-backed and likely to support improved digestion in healthy individuals.

It might be best to find a more comprehensive probiotic blend for the high price if you want to support the digestive process. If you are seeking weight reduction support, Bio X4’s ingredients might be inadequate to deliver the desired results.

Frequently Asked Questions

Does Bio X4 help you lose weight?

Bio X4 has ingredients aimed at helping consumers lose weight, but the science behind these claims isn’t completely sound. Green tea extract may help with weight loss and weight loss in some individuals. Caralluma Fimbriata may help curb appetite, but the science behind this is inconsistent.

Is Nucific FDA approved?

The FDA does not approve vitamins or supplements in the United States, and for this reason Nucific is not FDA-approved. Bio X4 is third-party tested for quality and purity.

What are the side effects of Bio X4?

Possible side effects of Bio X4 include gastrointestinal issues like bloating and flatulence. Some users may experience allergies to the ingredients, so be sure to check with your doctor before starting Bio X4.

How long does Bio X4 last?

One bottle of Bio X4 will only last between 15-30 days if you are taking the recommended dosage or the maximum dosage. Remaining on high doses of this supplement can become pricey quickly at $99 per bottle.

Can I take Bio X4 without food?

According to their website, it is best to take Bio X4 with food. Certain ingredients in this supplement, like green tea, may cause unwanted side effects if taken on an empty stomach.[23]


  1. Shirai, T., Hayakawa, H., Akiyama, J., Iwata, M., Chida, K., Nakamura, H., Taniguchi, M. and Khaled Reshad (2003). Food allergy to green tea. The Journal of Allergy and Clinical Immunology, [online] 112(4), pp.805–806. doi:
  2. Alessandro Di Cerbo, Palmieri, B., Aponte, M., Julio César Morales‐Medina and Iannitti, T. (2015). Mechanisms and therapeutic effectiveness of lactobacilli. Journal of Clinical Pathology, [online] 69(3), pp.187–203. doi:
  3. Tojo, R., Suárez, A., Marta García Clemente, Clara, Abelardo Margollés, Gueimonde, M. and Ruas‐Madiedo, P. (2014). Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis. World Journal of Gastroenterology, [online] 20(41), pp.15163–15163. doi:
  4. Peyrot, C. and Paul A.S. Breslin (2016). Salivary Amylase: Digestion and Metabolic Syndrome. Current Diabetes Reports, [online] 16(10). doi:
  5. Peyrot, C. and Paul A.S. Breslin (2016). Salivary Amylase: Digestion and Metabolic Syndrome. Current Diabetes Reports, [online] 16(10). doi:
  6. Chakraborty, A., Mitra, S., Trina Ekawati Tallei, Abu Montakim Tareq, Firzan Nainu, Donatella Cicia, Kuldeep Dhama, Talha Bin Emran, Jesús Simal-Gándara and Capasso, R. (2021). Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective. Life, [online] 11(4), pp.317–317. doi:
  7. Yasaman Pirahanchi and Sharma, S. (2023). Biochemistry, Lipase. [online] Available at:
  8. Musiał, C., Alicja Kuban–Jankowska and Górska–Ponikowska, M. (2020). Beneficial Properties of Green Tea Catechins. International Journal of Molecular Sciences, [online] 21(5), pp.1744–1744. doi:
  9. Colonetti, L., Antônio José Grande, Indianara Reynaud Toreti, Luciane Bisognin Ceretta, Inês, M. and Tamy Colonetti (2022). Green tea promotes weight loss in women with polycystic ovary syndrome: Systematic review and meta-analysis. Nutrition Research, [online] 104, pp.1–9. doi:
  10. Griggs, J.L., Su, X. and Mathai, M.L. (2015). Caralluma fimbriata supplementation improves the appetite behavior of children and adolescents with Prader-Willi syndrome. North American Journal of Medical Sciences, [online] 7(11), pp.509–509. doi:
  11. Alternative Treatments for Weight Loss: Safety/Risks and Effectiveness of Anti-Obesity Medicinal Plants. (2015). International Journal of Food Properties. [online] doi:
  12. Arora, E., Vijay Khajuria, Tandon, V.R., Sharma, A., Mahajan, A., Gillani, Z. and Choudhary, N. (2015). To evaluate efficacy and safety of Caralluma fimbriata in overweight and obese patients: A randomized, single blinded, placebo control trial. Perspectives in Clinical Research, [online] 6(1), pp.39–39. doi:
  13. Griggs, J.L., Su, X. and Mathai, M.L. (2015). Caralluma fimbriata supplementation improves the appetite behavior of children and adolescents with Prader-Willi syndrome. North American Journal of Medical Sciences, [online] 7(11), pp.509–509. doi:
  14. Ranil Jayawardena, Francis, T.V., Sachith Abhayaratna and Ranasinghe, P. (2021). The use of Caralluma fimbriata as an appetite suppressant and weight loss supplement: a systematic review and meta-analysis of clinical trials. BMC complementary medicine and therapies, [online] 21(1). doi:
  15. Legeay, S., Rodier, M., Fillon, L., Faure, S. and Clere, N. (2015). Epigallocatechin Gallate: A Review of Its Beneficial Properties to Prevent Metabolic Syndrome. Nutrients, [online] 7(7), pp.5443–5468. doi:
  16. Elahe Esmaeilpanah, Bibi Marjan Razavi and Hosseinzadeh, H. (2021). Green tea and metabolic syndrome: A 10-year research update review. DOAJ (DOAJ: Directory of Open Access Journals), [online] 24(9), pp.1159–1172. doi:
  17. Elahe Esmaeilpanah, Bibi Marjan Razavi and Hosseinzadeh, H. (2021). Green tea and metabolic syndrome: A 10-year research update review. DOAJ (DOAJ: Directory of Open Access Journals), [online] 24(9), pp.1159–1172. doi:
  18. Saviano, A., Brigida, M., Migneco, A., Gunawardena, G., Zanza, C., Marcello Candelli, Franceschi, F. and Ojetti, V. (2021). Lactobacillus Reuteri DSM 17938 (Limosilactobacillus reuteri) in Diarrhea and Constipation: Two Sides of the Same Coin? Medicina-lithuania, [online] 57(7), pp.643–643. doi:
  19. Ianiro, G., Pecere, S., Giorgio, V., Gasbarrini, A. and Cammarota, G. (2016). Digestive Enzyme Supplementation in Gastrointestinal Diseases. Current Drug Metabolism, [online] 17(2), pp.187–193. doi:
  20. Elahe Esmaeilpanah, Bibi Marjan Razavi and Hosseinzadeh, H. (2021). Green tea and metabolic syndrome: A 10-year research update review. DOAJ (DOAJ: Directory of Open Access Journals), [online] 24(9), pp.1159–1172. doi:
  21. Farzaneh Sotoudegan, Marzieh Daniali, Hassani, S., Shekoufeh Nikfar and Abdollahi, M. (2019). Reappraisal of probiotics’ safety in human. Food and Chemical Toxicology, [online] 129, pp.22–29. doi:
  22. Chen, I-Ju., Liu, C.-Y., Chiu, J.-P. and Cheng Hsiung Hsu (2016). Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial. Clinical Nutrition, [online] 35(3), pp.592–599. doi:
  23. Zeinab Bedrood, Rameshrad, M. and Hosseinzadeh, H. (2018). Toxicological effects of Camellia sinensis (green tea): A review. Phytotherapy Research, [online] 32(7), pp.1163–1180. doi:

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