Best Weight Loss Supplements – Top 10 Supplements To Lose Weight Effectively In 2023

Christine VanDoren, Nutritionist
Kathy Shattler, MS, RDN

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Learn about the ingredients of the ten best weight loss supplements to discover which would work best for you and your goals in 2023.
best weight loss supplements
Weight loss supplements can help you burn fat.

Did you know that over 15% of adults in the United States[1] have reported using weight loss supplements as part of their strategy to burn fat? 

Finding the best weight loss supplements is an important step in developing a healthier fitness routine. The struggle to get in shape and lose belly fat can appear overwhelming in today’s world of endless options. 

In this piece, we intend to demystify the world of weight loss supplements to help you make the best choice. In this guide, we will explore the perks and drawbacks of these products and separate reality from fiction. 

Whether you want to burn stubborn body fat or start a holistic weight loss journey, our insights will provide the knowledge you need to make wise decisions. It is time to dive in.

Top 10 Best Weight Loss Supplements

Is It Safe To Use Weight Loss Supplements?

The use of weight loss pills is contentious. Although some supplements guarantee immediate benefits, their safety and efficacy are uncertain since supplements are generally not subject to FDA evaluation.

However, there are prescription weight loss pills available, though they may have side effects and are only for specific cases of obesity.  

So, the safest way to lose weight is to make lifestyle changes because sustainable weight loss mainly depends on a healthy, hypocaloric diet and consistent exercise. Always put safety first and get advice from a medical professional before choosing any weight loss pill.

10 Best Weight Loss Supplements In 2023


  • Reduces cravings and burns fat.
  • Helps balance energy and mood levels.
  • 60-day money-back guarantee.
  • Contains a high dose of caffeine.


See PhenQ Reviews

PhenQ was manufactured at an FDA-registered facility. It promises a five-in-one benefit daily formula, including their patented combination, α-Lacys Reset®, which aids in weight loss.

Generally, PhenQ helps you lose weight by burning fat, reducing fat accumulation, diminishing food cravings, boosting energy, and balancing mood. The ingredients in PhenQ include α-Lacys Reset®, chromium picolinate, caffeine, capsimax powder, nopal cactus, l-carnitine fumarate, Innoslim, B-vitamins, and iodine.

α-Lacys Reset® is a combination of alpha lipoic acid,[2] cysteine, and magnesium. Research has found that these compounds can be used in weight management.[3]

Chromium picolinate[4] in 200 mcg to 1,000 mcg doses may help lower your appetite and reduce your calorie intake. According to supporting research, there is only 20 mcg of this mineral in PhenQ, so whether it has enough chromium in it to accomplish claimed effects is questionable. The RDA for chromium is 25-35 mcg per day.

Caffeine helps speed up fat metabolism. Studies show that caffeine promotes weight reduction.[5]

Capsimax powder is made from the extract of cayenne red pepper. It contributes to body fat reduction[6] at doses of 4 mg/day. Capsimax is a blend of 50 mg of capsimax powdered capsaicinoids.

Nopal cactus helps fat metabolism by blocking absorption and also promotes satiety. Research shows that cactus fiber promotes weight loss.[7]

The B vitamins promote weight loss by acting as cofactors in metabolism[8]-related enzyme activities in those who are deficient in these nutrients.

A bottle of PhenQ, which contains 60 capsules, costs $69.99. Buying two bottles at $139.99 gets you a free bottle while buying three bottles at $209.99 gets you two free bottles. Every purchase comes with free shipping.


  • Enhances fat metabolism.
  • 90-day money-back guarantee.
  • Good Manufacturing Practices-certified. Manufactured in an FDA-registered facility.
  • It is made only for women.


See Leanbean Reviews

Leanbean is a U.K.-based brand that expertly prepares weight loss supplements designed specifically for women. It promises to help you reach your fitness goals by supporting metabolism, increasing satiety, and reducing fatigue to encourage exercise.

It does all these with its tested ingredients, which include glucomannan,[9] vitamin B12, vitamin B6,[8] choline,[10] green coffee,[11] and acai berry.[12]

Glucomannan is obtained from the Konjac root extract. It induces weight loss by suppressing appetite. A 2020 study shows that glucomannan reduces body weight[9] in overweight and obese people. There are 3 grams of glucomannan in Leanbean.

Vitamins B6 and B12 support enzyme activity during metabolism.

Choline supports weight loss by increasing fat burning. Studies reveal that choline supplementation could help reduce fat[10] in the body. Participants in the study took 1 gram twice daily to achieve this effect. There is 82.5 mg in Leanbean.

Green coffee can increase lean mass[11] in the body. Acai berries[12] are a fruit for weight loss that may lower blood cholesterol levels.

To get the best from this supplement, take two capsules with at least one to two glasses of water 30 minutes before breakfast, lunch, and dinner. 

A bottle of Leanbean, which is a month’s supply, contains 180 capsules and costs $59.99. The 60-day supply of two bottles (360 capsules) costs $119.98 and comes with free shipping to the UK and USA.


  • Vegan-friendly.
  • Free shipping worldwide.
  • Made in an FDA-registered facility.
  • Contains high doses of caffeine.


See PhenGold Reviews

PhenGold is a non-prescription weight loss medication manufactured in the U.S. under a GMP-certified and FDA-registered facility, using ingredients free from genetically modified ingredients or non-GMO.

PhenGold’s weight loss mechanisms include burning fat, reducing cravings, and boosting body metabolism, mood, and energy. Its natural and clinically proven ingredients[13] are caffeine, l-tyrosine,[14] Rhodiola, green tea, green coffee, l-theanine,[15] cayenne pepper,[16] vitamins B3, B6, B12,[8] and dimethylaminoethanol or DMAE. 

Caffeine stimulates fat breakdown, l-tyrosine enhances metabolic processes, and Rhodiola[17] also promotes fat breakdown and has anti-obesity effects.

Green tea regulates obesity-inducing hormones. Green coffee improves the body’s lean mass. Cayenne pepper stimulates fat-burning 

Vitamins B3, B6, and B12 support the enzymatic process in metabolism. 

The manufacturer recommends taking a dose of three capsules every morning before breakfast and your workouts.

A month’s supply of PhenGold is a bottle with 90 capsules, which costs $64.99. Two months’ supply gets you a free month at $129.98, and three months’ supply gets you two free months’ supply at $194.97. 

In addition, you can subscribe and save 20% for one month at $51.99. The manufacturer offers a 100-day money-back guarantee and a refund policy, which allows you to return unused items within two weeks of purchase.

Hourglass Fit

Hourglass Fit
  • Helps you get well-toned muscles.
  • Caffeine-free.
  • Manufacturer offers free shipping.
  • Formulated for women only.


See Hourglass Fit Reviews

Hourglass Fit is a U.K.-based brand that produces not just dietary supplements but also one of the best weight loss pills for women.

Hourglass Fit promises women who use their product a flat stomach, an hourglass waist, firm and shaped glutes, and well-toned legs and arms. The ingredients used are Konjac root extract, capsimax,[6] zinc,[18] vitamins B2, B6, and B12,[8] chromium picolinate, and Griffonia simplicifolia[19] extract. 

Konjac root extract helps reduce blood cholesterol levels and suppresses appetite.

Capsimax stimulates the metabolism. Vitamins B2, B6, and B12 facilitate fat metabolic processes. 

Chromium picolinate suppresses appetite and food cravings. Griffonia increases satiety and reduces cravings.

Take one capsule with a glass of water four times daily for best results.

There are different Hourglass Fit packages you can purchase. While the one-month package, which contains 120 capsules, costs $60.00, the two-month package, containing 240 capsules, with gifts, costs $120.00. The Ultimate Slim package has 480 capsules total with other gifts and costs $180.00. 

As for their return policy, you can return unused and unopened items if you have received your order within the last 30 days for the U.S. or Canada or within 14 days for the U.K. and the rest of the world.

Instant Knockout

Instant Knockout
  • Unique thermogenic formulation for 24-hour fat-burning.
  • It is vegetarian- and vegan-friendly.
  • Contains scientifically proven ingredients.
  • Contains caffeine in high doses.


See Instant Knockout Reviews

Instant Knockout has recently garnered attention in the fitness industry. Roar Ambition Ltd., a U.K.-based firm renowned for its high-end fitness supplements, manufactured Instant Knockout, which has a good reputation for helping to promote fat reduction and improve workout performance.

While taking Instant Knockout, users report increased energy levels, improved focus, and reduced cravings. This can be especially beneficial during low-calorie weight loss diets and intense workouts.

The ingredients include glucomannan, green tea extract, caffeine, cayenne pepper seeds, black pepper extract, vitamin D3, vitamin B6, vitamin B12, and l-theanine.[15]

The pricing for Instant Knockout varies depending on the package chosen, with discounts for bulk purchases. The Cut one-month supply package costs $65.00, the Cutting Stack two-month supply package costs $130.00, and the Ultimate Cutting Stack four-month supply package costs $195.00. 

Their return policy is similar to Hourglass Fit. Consequently, you can return unused and unopened items for customers in the U.S. or Canada if you have received your order within the last 30 days. Meanwhile, those in the U.K. and the rest of the world can do the same if the order comes within the last 14 days.


Powher Cut
  • Enhances exercise performance.
  • Promotes healthy body metabolism.
  • Manufactured in an FDA and GRC-registered facility.
  • It is made for only women.
  • Contains caffeine in high doses.


See Powher Reviews

Powher is a weight loss supplement manufactured by Ultimate Life Ltd in a facility that Governance, Risk, and Compliance and the FDA register. This product comes with a blend of benefits, such as safe and effective weight loss for women. It offers a natural and science-backed approach, catering specifically to female metabolism and hormonal needs.

The supplement contains ingredients such as enxtra, green coffee beans, leucine, beta-alanine,[20] oxyjun, rednite, folic acid, vitamin B6, vitamin B12, coconut water powder, and l-tyrosine. These ingredients work together to reduce appetite, support metabolism, and boost energy levels. 

Enxtra[21] is an ingredient that provides you with energy and alertness like caffeine does but without the crash.

Oxyjun is an extract of Arjuna that may support endurance and heart health.[22] Rednite is a beetroot powder[23] that boosts athletic individuals by helping reduce fatigue while improving energy and stamina.

One bottle of Powher Up costs $45.00. Two bottles cost $90.00 with free shipping to the US and UK, and the Ultimate Powher Up Pack costs $135.00 with free shipping worldwide. 

Their return policy covers unused items returned within seven days of purchase. You also get to enjoy a 90-day money-back guarantee if you are unsatisfied with the product.


  • Made of 100% natural ingredients.
  • Suppresses appetite.
  • Supports body metabolism.
  • Formulated mainly for women.


See Trimtone Reviews

Trimtone is one of the best weight loss products known for its natural approach to aiding weight loss. Health Nutrition Limited, a registered company in the U.K., manufactures the supplement.

The manufacturer places a high priority on transparency and safety. The formula, which contains natural ingredients known for their benefits in weight loss, shows their commitment to quality. The main advantage of Trimtone is its ability to increase metabolism, which enables users to burn calories more effectively. 

This is made possible by using ingredients like caffeine, green tea extract, green coffee bean extract, Grains of paradise,[24] and glucomannan. These combined help stimulate weight loss through thermogenesis and decreased appetite.

The Trimtone packages are one month’s supply for $49.99, two months’ supply with a free month’s supply for $99.99, and three months’ supply with two free months’ supply for $149.99. 

You can return your order and get a refund within 14 days of purchase, provided they are undamaged or unopened. They offer a 100-day money-back guarantee.

Burn Lab Pro

burn lab pro
  • It uses 100% natural ingredients.
  • Vegan-friendly.
  • Burns fat and maintains muscle.
  • May not be compatible with certain medical conditions or medications.


See Burn Lab Pro Reviews

Burn Lab Pro is a dietary supplement for weight loss that has been recognized for its distinctive strategy for promoting healthy weight management. Opti-Nutra, a notable brand known for its premium dietary supplements intended to provide people with a safe means to lose fat, manufactures Burn Lab Pro.

Burn Lab Pro boosts your endurance during workouts, supports muscle growth and quick and healthy recovery after intense exercises, and promotes lean muscle gains. 

The ingredients in the supplement are ForsLean® or Coleus forskohlii,[25] hydroxy ß-methyl butyrate or HMB,[26] capsimax, NutriGenesis® GTF chromium, and Bioperine black Pepper extract. 

For the best outcome, you should take two to four capsules 30 minutes before your exercises or workouts.

The pricing is based on their various packages. The four-month supply (three boxes) package with one free box costs $106.20, the two-month supply (two boxes) package costs $70.80, and the one-month supply (one box) package costs $35.40. 

More importantly, you have a 30-day money-back guarantee if you are unsatisfied with the product. You can also return unopened orders within 14 days of purchase.


  • Organic and caffeine-free.
  • Boosts the immune system.
  • Enhances body fat metabolism and increases energy.
  • Not evaluated by the FDA.


See Phen24 Reviews

Phen24 offers a 2-in-1 approach to achieving your weight loss goals. Developed by the renowned company BUQ Group Ltd, Phen24 aims to provide a 24-hour solution to support your weight loss journey.

One of the benefits of Phen24 is its unique day-and-night formula. It consists of two pills, one for daytime and another for nighttime. The daytime pill is designed to boost your metabolism, increase energy levels, and enhance calorie burning. 

Meanwhile, the nighttime pill promotes better sleep, reduces evening cravings, and supports your body’s natural fat-burning processes during rest. The ingredients for the Phen24 day formula include l-phenylalanine,[27] guarana,[28] ashwagandha,[29] and cayenne. The night formula contains choline bitrate, l-theanine, Griffonia, and l-arginine. 

L-phenylalanine[27] is an amino acid that may stimulate fat metabolism. Guarana activates brown adipose tissue.[28] It also reduces appetite.

A 2017 study shows that ashwagandha contributes to weight management[29] and reduces anxiety.

Cayenne aids fat metabolism, while choline bitrate promotes fat burning. L-theanine stimulates thermogenesis.[15]

Griffonia contains 5-Hydroxytryptophan or 5-HTP, which research has shown to increase fullness and reduce calorie intake. Historical research shows that oral spray administration of Griffonia increases satiety.[30] You should take Phen24 Day every morning alongside breakfast. For Phen24 Night, take two capsules 15 minutes before dinner, with one to two glasses of water.

Transparent Labs Fat Burner Stim-Free

Transparent Labs Fat Burner Stim-Free
  • 100% natural, gluten-free, and non-GMO.
  • Contains no artificial sweeteners, flavors, or colors.
  • Third-party lab tested.
  • May not be suitable for people who are pregnant or nursing or those with underlying medical conditions.


See Transparent Labs Reviews

Transparent Lab, a U.S.-based company, manufactures Transparent Labs Fat Burner Stim-FreeTrimtone.

Transparent Labs Fat Burner Stim-FreeTrimtone acts as a powerful thermogenic. It also acts as an appetite suppressant, aiding calorie control and preventing overeating by stimulating fullness. 

The ingredients used include green tea leaf extract, Forslean,[25] l-theanine, capsimax or red pepper extract, and Bioperine black pepper extract.

The manufacturer recommended taking two capsules twice daily, 30 to 60 minutes before meals, with a glass of water. For the first three days, start with one capsule twice daily to evaluate tolerance and then gradually increase the dosage. 

More importantly, avoid taking more than two capsules in a four-hour window, and never take more than four in a 24-hour window. Try not to take it four hours before bed.

A one-time purchase costs $54.99. However, with a subscription, you get 10% off and free shipping. If you are unsatisfied with your order, the brand promises you a full refund or store credit for the item’s value within 30 days of delivery.

How To Choose Suitable Weight Loss Supplements

Whether or not you opt for a prescription weight loss drug, choosing suitable weight loss supplements requires careful consideration to ensure they align with your health goals. First, prioritize supplements focusing on sustainable results rather than quick fixes like detox diets. Look for those that support your body’s natural metabolism and help you maintain a healthy body weight.

Always check the labels for transparency. Reputable businesses usually offer thorough details on the ingredients, doses, and possible side effects. Before commencing any supplement program, you should speak with a healthcare expert, especially if you have underlying health issues.

Finally, remember that a healthy diet rich in fruits, vegetables, and lean protein and regular exercise go hand in hand with weight loss supplements to produce the best results. Avoid pills that promise immediate benefits without any lifestyle modification. Put your long-term health first and go for supplements that will further your quest for sustained weight loss.

Common Ingredients In Supplements For Weight Loss

Common ingredients used in weight loss supplements include green tea, B vitamins, caffeine, cayenne pepper, and l-tyrosine. Many supplements utilize the same ingredients, with some of them varying slightly.

Many of these ingredients do have the potential to help you along your weight loss journey by providing the body with the nutrients it needs while stimulating your metabolism. 

Certain ingredients, like nopal cactus and glucomannan, may also suppress your appetite, making practicing portion control much more doable. Limiting your food intake will ultimately help you lose weight.

Potential Side Effects

As with many other drugs and supplements, weight loss medications can also exert certain side effects. These side effects may vary depending on the specific supplement and its ingredients, but here are some common concerns:

  • Digestive problems: Many weight loss supplements contain ingredients like fiber, green tea extract, or caffeine, which can lead to digestive issues such as diarrhea, constipation, or stomach cramps.
  • Nervousness and restlessness: Supplements containing stimulants like caffeine can cause increased restlessness and even anxiety, especially in sensitive individuals.
  • Increased heart rate: Stimulant-based supplements may also lead to elevated heart rate and high blood pressure, posing risks for those with heart conditions.
  • Sleep disturbances: Stimulants can interfere with sleep patterns, leading to insomnia or disrupted sleep, negatively affecting overall health.
  • Liver damage: Certain weight loss supplements, particularly those containing high doses of specific ingredients, have been associated with liver damage. You should research the safety of the ingredients in any weight loss supplement before purchasing it.
  • Dependency and tolerance: Some individuals may develop a tolerance to weight loss supplements over time, requiring higher doses for the same effects. This can potentially lead to dependency and addiction.
  • Interactions with medications: Weight loss supplements can interact with medications, leading to adverse reactions or reduced effectiveness of prescribed drugs.

It is essential to consult a healthcare professional before using weight loss supplements, especially if you have underlying health conditions or are taking medications. If the supplement you are using causes you any discomfort or symptoms, it is advisable to discontinue it.


The world of supplements offers a wide range of options, each with its own pros and cons, for those looking for effective weight loss pills. Our review of these top ten weight loss pills provided insight into the wide range of products available to support your fitness mission.

Although some top-rated weight loss supplements show potential, it is essential to remember that no single weight loss option works for everyone. The secret is to select a supplement that fits your needs, preferences, and ambitions. To make wise decisions, consider your needs, speak with healthcare professionals, and prioritize research and scientific support for ingredients.

We must also acknowledge that supplements are not a magic wand to ward off evil pounds. Their effectiveness often depends on a holistic approach, including a balanced diet and regular exercise. Moreover, potential side effects underscore the importance of cautious and responsible supplementation.

Frequently Asked Questions

Are there any weight loss pills that actually work?

Many weight loss pills work, as evidenced by scientific research and customer reviews.

What is the #1 fat burner?

Choosing the best fat burner is difficult as weight loss supplements work differently for different people.

What supplements should I take to lose weight?

The ideal supplement for you will depend on what your body tolerates. Look through the ingredients list and see which ingredients you are not sensitive to. Also, seek the advice of your physician.

What are the best weight loss supplements?

The best weight-loss supplements include the top ten in this piece. Feel free to try any according to your preferences and see which works for you.


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